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Strategies to reduce the risks of mRNA drug and vaccine toxicity
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …
enabled the rapid development and administration of billions of coronavirus disease 2019 …
Advances in spheroids and organoids on a chip
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …
medicine and drug screening. They replicate the structural and functional characteristics of …
Organ-on-a-chip: recent breakthroughs and future prospects
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
Beyond polydimethylsiloxane: alternative materials for fabrication of organ-on-a-chip devices and microphysiological systems
Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …
[HTML][HTML] Emerging trends in organ-on-a-chip systems for drug screening
New drug discovery is under growing pressure to satisfy the demand from a wide range of
domains, especially from the pharmaceutical industry and healthcare services. Assessment …
domains, especially from the pharmaceutical industry and healthcare services. Assessment …
Advances in organ-on-a-chip materials and devices
The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …
Spheroid engineering in microfluidic devices
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …
biophysical and biochemical cellular responses. However, these culture methods, having …
[HTML][HTML] Engineered liver-on-a-chip platform to mimic liver functions and its biomedical applications: A review
J Deng, W Wei, Z Chen, B Lin, W Zhao, Y Luo, X Zhang - Micromachines, 2019 - mdpi.com
Hepatology and drug development for liver diseases require in vitro liver models. Typical
models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte …
models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte …
Liver organ-on-chip models for toxicity studies and risk assessment
The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …
functions in the body, including homeostasis, synthesis of essential components, nutrient …