Cerebral cavernous malformation: what a practicing clinician should know

KD Flemming, G Lanzino - Mayo Clinic Proceedings, 2020 - Elsevier
Cavernous malformations (CMs) are angiographically occult, low-flow vascular
malformations of the central nervous system. They are acquired lesions, with approximately …

Cerebral cavernous malformations, developmental venous anomaly, and its coexistence: a review

PS Idiculla, D Gurala, J Philipose, K Rajdev… - European …, 2020 - karger.com
Abstract Background: Cerebral cavernous malformations (CCMs) are intracranial vascular
malformations that can exist as a single lesion or mixed vascular lesions. The most common …

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations

T Hong, X **ao, J Ren, B Cui, Y Zong, J Zou, Z Kou… - Brain, 2021 - academic.oup.com
Cavernous malformations affecting the CNS occur in∼ 0.16–0.4% of the general population.
The majority (85%) of cavernous malformations are in a sporadic form, but the genetic …

Cerebral cavernous malformations: typical and atypical imaging characteristics

D Kuroedov, B Cunha, J Pamplona… - Journal of …, 2023 - Wiley Online Library
Cavernous malformations (CMs) are benign vascular malformations that maybe seen
anywhere in the central nervous system. They are dynamic lesions, growing or shrinking …

Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot …

S Lanfranconi, E Scola, JMTA Meessen… - The Lancet …, 2023 - thelancet.com
Background Observations in people with cerebral cavernous malformations, and in
preclinical models of this disorder, suggest that the β-blocker propranolol might reduce the …

Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations

J Ren, Y Huang, Y Ren, T Tu, B Qiu, D Ai, Z Bi, X Bai… - Brain, 2023 - academic.oup.com
Cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …

mTORC1 inhibitor rapamycin inhibits growth of cerebral cavernous malformation in adult mice

L Li, AA Ren, S Gao, YS Su, J Yang, J Bockman… - Stroke, 2023 - ahajournals.org
BACKGROUND: Cerebral cavernous malformations (CCMs) are vascular malformations that
frequently cause stroke. CCMs arise due to loss of function in one of the genes that encode …

Propranolol for familial cerebral cavernous malformation (Treat_CCM): study protocol for a randomized controlled pilot trial

S Lanfranconi, E Scola, GA Bertani, B Zarino, R Pallini… - Trials, 2020 - Springer
Abstract Background Cerebral cavernous malformations (CCMs) are vascular malformations
characterized by clusters of enlarged leaky capillaries in the central nervous system. They …

Congenital Vascular and Lymphatic Diseases

R Jung, CM Trivedi - Circulation Research, 2024 - ahajournals.org
Over the past several centuries, the integration of contemporary medical techniques and
innovative technologies, like genetic sequencing, have played a pivotal role in enhancing …

Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations

AK Ressler, DA Snellings, R Girard, CJ Gallione… - Nature …, 2023 - nature.com
Abstract Cerebral Cavernous Malformations (CCMs) are vascular malformations of the
central nervous system which can lead to moderate to severe neurological phenotypes in …