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Cerebral cavernous malformation: what a practicing clinician should know
KD Flemming, G Lanzino - Mayo Clinic Proceedings, 2020 - Elsevier
Cavernous malformations (CMs) are angiographically occult, low-flow vascular
malformations of the central nervous system. They are acquired lesions, with approximately …
malformations of the central nervous system. They are acquired lesions, with approximately …
Cerebral cavernous malformations, developmental venous anomaly, and its coexistence: a review
Abstract Background: Cerebral cavernous malformations (CCMs) are intracranial vascular
malformations that can exist as a single lesion or mixed vascular lesions. The most common …
malformations that can exist as a single lesion or mixed vascular lesions. The most common …
Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations
T Hong, X **ao, J Ren, B Cui, Y Zong, J Zou, Z Kou… - Brain, 2021 - academic.oup.com
Cavernous malformations affecting the CNS occur in∼ 0.16–0.4% of the general population.
The majority (85%) of cavernous malformations are in a sporadic form, but the genetic …
The majority (85%) of cavernous malformations are in a sporadic form, but the genetic …
Cerebral cavernous malformations: typical and atypical imaging characteristics
D Kuroedov, B Cunha, J Pamplona… - Journal of …, 2023 - Wiley Online Library
Cavernous malformations (CMs) are benign vascular malformations that maybe seen
anywhere in the central nervous system. They are dynamic lesions, growing or shrinking …
anywhere in the central nervous system. They are dynamic lesions, growing or shrinking …
Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot …
S Lanfranconi, E Scola, JMTA Meessen… - The Lancet …, 2023 - thelancet.com
Background Observations in people with cerebral cavernous malformations, and in
preclinical models of this disorder, suggest that the β-blocker propranolol might reduce the …
preclinical models of this disorder, suggest that the β-blocker propranolol might reduce the …
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations
J Ren, Y Huang, Y Ren, T Tu, B Qiu, D Ai, Z Bi, X Bai… - Brain, 2023 - academic.oup.com
Cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …
mTORC1 inhibitor rapamycin inhibits growth of cerebral cavernous malformation in adult mice
BACKGROUND: Cerebral cavernous malformations (CCMs) are vascular malformations that
frequently cause stroke. CCMs arise due to loss of function in one of the genes that encode …
frequently cause stroke. CCMs arise due to loss of function in one of the genes that encode …
Propranolol for familial cerebral cavernous malformation (Treat_CCM): study protocol for a randomized controlled pilot trial
Abstract Background Cerebral cavernous malformations (CCMs) are vascular malformations
characterized by clusters of enlarged leaky capillaries in the central nervous system. They …
characterized by clusters of enlarged leaky capillaries in the central nervous system. They …
Congenital Vascular and Lymphatic Diseases
R Jung, CM Trivedi - Circulation Research, 2024 - ahajournals.org
Over the past several centuries, the integration of contemporary medical techniques and
innovative technologies, like genetic sequencing, have played a pivotal role in enhancing …
innovative technologies, like genetic sequencing, have played a pivotal role in enhancing …
Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations
Abstract Cerebral Cavernous Malformations (CCMs) are vascular malformations of the
central nervous system which can lead to moderate to severe neurological phenotypes in …
central nervous system which can lead to moderate to severe neurological phenotypes in …