Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
Superoxide dismutases and superoxide reductases
Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …
Alzheimer's disease and gut microbiota
X Hu, T Wang, F ** - Science China Life Sciences, 2016 - Springer
Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates
with impaired cognition. Gut microbiota can modulate host brain function and behavior via …
with impaired cognition. Gut microbiota can modulate host brain function and behavior via …
Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
Neurodegenerative and neurological disorders by small inhaled particles
HJ Heusinkveld, T Wahle, A Campbell, RHS Westerink… - Neurotoxicology, 2016 - Elsevier
The world⿿ s population is steadily ageing and as a result, health conditions related to
ageing, such as dementia, have become a major public health concern. In 2001, it was …
ageing, such as dementia, have become a major public health concern. In 2001, it was …
[HTML][HTML] Amyotrophic lateral sclerosis: an update for 2013 clinical features, pathophysiology, management and therapeutic trials
PH Gordon - Aging and disease, 2013 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS), first described by Jean-Martin Charcot in the 1870s, is
an age-related disorder that leads to degeneration of motor neurons. The disease begins …
an age-related disorder that leads to degeneration of motor neurons. The disease begins …
Alzheimer's disease and the microbiome
S Bhattacharjee, WJ Lukiw - Frontiers in cellular neuroscience, 2013 - frontiersin.org
The recognition of the human microbiome (HM) as a substantial contributor to nutrition,
health and disease is a relatively recent one, and currently, peerreviewed studies linking …
health and disease is a relatively recent one, and currently, peerreviewed studies linking …
Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders
VN Uversky - Frontiers in aging neuroscience, 2015 - frontiersin.org
The recent years have witnessed a rise in the number of intrinsically disordered proteins
(IDPs), also known as hybrid proteins, which possess both structured domains and …
(IDPs), also known as hybrid proteins, which possess both structured domains and …
Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks
AM Hossini, M Megges, A Prigione, B Lichtner… - BMC genomics, 2015 - Springer
Background Alzheimer's disease (AD) is a complex, irreversible neurodegenerative
disorder. At present there are neither reliable markers to diagnose AD at an early stage nor …
disorder. At present there are neither reliable markers to diagnose AD at an early stage nor …
Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity
C Yang, EW Danielson, T Qiao… - Proceedings of the …, 2016 - National Acad Sciences
Mutations in the profilin 1 (PFN1) gene cause amyotrophic lateral sclerosis (ALS), a
neurodegenerative disease caused by the loss of motor neurons leading to paralysis and …
neurodegenerative disease caused by the loss of motor neurons leading to paralysis and …