Root of the tree: the significance, evolution, and origins of the ribosome
The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …
Peptides before and during the nucleotide world: An origins story emphasizing cooperation between proteins and nucleic acids
Recent developments in Origins of Life research have focused on substantiating the
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …
Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules
DGJ Smethurst, N Shcherbik - Journal of Biological Chemistry, 2021 - ASBMB
Metal ions provide considerable functionality across biological systems, and their utilization
within biomolecules has adapted through changes in the chemical environment to maintain …
within biomolecules has adapted through changes in the chemical environment to maintain …
The peptidyl transferase center: a window to the past
SUMMARY In his 2001 article,“Translation: in retrospect and prospect,” the late Carl Woese
made a prescient observation that there was a need for the then-current view of translation …
made a prescient observation that there was a need for the then-current view of translation …
One-Pot De Novo Synthesis of [4Fe-4S] Proteins Using a Recombinant SUF System under Aerobic Conditions
Fe–S clusters are essential cofactors mediating electron transfer in respiratory and
metabolic networks. However, obtaining active [4Fe-4S] proteins with heterologous …
metabolic networks. However, obtaining active [4Fe-4S] proteins with heterologous …
Selective metal chelation by a thiosemicarbazone derivative interferes with mitochondrial respiration and ribosome biogenesis in Candida albicans
X Duan, Z **e, L Ma, X **, M Zhang, Y Xu… - Microbiology …, 2022 - Am Soc Microbiol
Metal chelation is generally considered as a promising antifungal approach but its specific
mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert …
mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert …
The czcD (NiCo) Riboswitch Responds to Iron(II)
J Xu, JA Cotruvo Jr - Biochemistry, 2020 - ACS Publications
Iron is essential for nearly every organism, and mismanagement of its intracellular
concentrations (either deficiency or excess) contributes to diminished virulence in human …
concentrations (either deficiency or excess) contributes to diminished virulence in human …
The regulatory role of Fur-encoding SCLAV_3199 in iron homeostasis in Streptomyces clavuligerus
Iron homeostasis is strictly regulated by complex cascades connected with secondary
metabolism in bacteria. Ferric uptake regulators ('Fur's), siderophores, efflux systems, and …
metabolism in bacteria. Ferric uptake regulators ('Fur's), siderophores, efflux systems, and …
Iron-mediated degradation of ribosomes under oxidative stress is attenuated by manganese
Protein biosynthesis is fundamental to cellular life and requires the efficient functioning of
the translational machinery. At the center of this machinery is the ribosome, a …
the translational machinery. At the center of this machinery is the ribosome, a …
Goldilocks and RNA: where Mg2+ concentration is just right
Magnesium, the most abundant divalent cation in cells, catalyzes RNA cleavage but also
promotes RNA folding. Because folding can protect RNA from cleavage, we predicted a …
promotes RNA folding. Because folding can protect RNA from cleavage, we predicted a …