Cholesterol modulates the bilayer structure of biological membranes in multiple ways. It
changes the fluidity, thickness, compressibility, water penetration and intrinsic curvature of …

Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Cell membranes are composed of a lipid bilayer, containing proteins that span the bilayer
and/or interact with the lipids on either side of the two leaflets. Although recent advances in …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

Signal transduction is initiated by complex protein–protein interactions between ligands,
receptors and kinases, to name only a few. It is now becoming clear that lipid micro …

Influenza A virus causes seasonal epidemics, sporadic pandemics and is a significant
global health burden. Influenza virus is an enveloped virus that contains a segmented …

▪ Abstract Views of how cell membranes are organized are presently changing. The lipid
bilayer that constitutes these membranes is no longer understood to be a homogeneous …

It is well known that separate domains with different lipid compositions can exist in
liposomes containing mixtures of different phospholipids. The question of whether cellular …

The physiological importance of cholesterol in the cell plasma membrane has attracted
increased attention in recent years. Consequently, the use of methods of controlled …

Mammalian cell membranes are composed of a complex array of glycerophospholipids and
sphingolipids that vary in head-group and acyl-chain composition. In a given cell type …