Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

[HTML][HTML] Imaging perivascular space structure and function using brain MRI

G Barisano, KM Lynch, F Sibilia, H Lan, NC Shih… - Neuroimage, 2022 - Elsevier
In this article, we provide an overview of current neuroimaging methods for studying
perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing …

The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts

G Barisano, F Sepehrband, HR Collins… - Proceedings of the …, 2022 - pnas.org
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid
compartments and visual acuity problems known as spaceflight-associated neuro-ocular …

A review of alterations to the brain during spaceflight and the potential relevance to crew in long-duration space exploration

M Roy-O'Reilly, A Mulavara, T Williams - npj Microgravity, 2021 - nature.com
During spaceflight, the central nervous system (CNS) is exposed to a complex array of
environmental stressors. However, the effects of long-duration spaceflight on the CNS and …

Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions

D Tesei, A Jewczynko, AM Lynch, C Urbaniak - Life, 2022 - mdpi.com
During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …

Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight

KE Hupfeld, SB Richmond, HR McGregor… - Scientific Reports, 2022 - nature.com
Humans are exposed to extreme environmental stressors during spaceflight and return with
alterations in brain structure and shifts in intracranial fluids. To date, no studies have …

Brain and behavioral evidence for reweighting of vestibular inputs with long-duration spaceflight

KE Hupfeld, HR McGregor, V Koppelmans… - Cerebral …, 2022 - academic.oup.com
Microgravity alters vestibular signaling. In-flight adaptation to altered vestibular afferents is
reflected in post-spaceflight aftereffects, evidenced by declines in vestibularly mediated …

Impact of different ground-based microgravity models on human sensorimotor system

A Saveko, M Bekreneva, I Ponomarev… - Frontiers in …, 2023 - frontiersin.org
This review includes current and updated information about various ground-based
microgravity models and their impact on the human sensorimotor system. All known models …

Long-term space missions' effects on the human organism: what we do know and what requires further research

M Tomsia, J Cieśla, J Śmieszek, S Florek… - Frontiers in …, 2024 - frontiersin.org
Space has always fascinated people. Many years have passed since the first spaceflight,
and in addition to the enormous technological progress, the level of understanding of human …

The effects of long duration spaceflight on sensorimotor control and cognition

GD Tays, KE Hupfeld, HR McGregor… - Frontiers in neural …, 2021 - frontiersin.org
Astronauts returning from spaceflight typically show transient declines in mobility and
balance. Other sensorimotor behaviors and cognitive function have not been investigated as …