Genetics of glutamate and its receptors in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …
deficits in social interaction skills, impaired communication, and repetitive and restricted …
[HTML][HTML] Allosteric modulation of GPCRs: new insights and potential utility for treatment of schizophrenia and other CNS disorders
G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent
advances have greatly expanded our understanding of these receptors as complex …
advances have greatly expanded our understanding of these receptors as complex …
Neural mechanisms underlying repetitive behaviors in rodent models of autism spectrum disorders
T Gandhi, CC Lee - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …
alterations in social interaction, communication, and repetitive behaviors. Genetic and …
Midbrain dopamine neurons arbiter OCD-like behavior
J Xue, D Qian, B Zhang, J Yang, W Li… - Proceedings of the …, 2022 - National Acad Sciences
The neurobiological understanding of obsessive–compulsive disorder (OCD) includes
dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive …
dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive …
International union of basic and clinical pharmacology. CXI. Pharmacology, signaling, and physiology of metabotropic glutamate receptors
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …
Reinforcement learning detuned in addiction: integrative and translational approaches
Suboptimal decision-making strategies have been proposed to contribute to the
pathophysiology of addiction. Decision-making, however, arises from a collection of …
pathophysiology of addiction. Decision-making, however, arises from a collection of …
The complex formed by group I metabotropic glutamate receptor (mGluR) and Homer1a plays a central role in metaplasticity and homeostatic synaptic scaling
G-protein-coupled receptors can be constitutively activated following physical interaction
with intracellular proteins. The first example described was the constitutive activation of …
with intracellular proteins. The first example described was the constitutive activation of …
Strengthened inputs from secondary motor cortex to striatum in a mouse model of compulsive behavior
Hyperactivity in striatum is associated with compulsive behaviors in obsessive-compulsive
disorder (OCD) and related illnesses, but it is unclear whether this hyperactivity is due to …
disorder (OCD) and related illnesses, but it is unclear whether this hyperactivity is due to …
[HTML][HTML] Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior
JM Malgady, A Baez, ZB Hobel, K Jimenez, J Goldfried… - Cell reports, 2023 - cell.com
Deletion of the obsessive-compulsive disorder (OCD)-associated gene SAP90/PSD-95-
associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at …
associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at …
Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice
KI Ramírez-Armenta, H Alatriste-León… - …, 2022 - nature.com
Excessive grooming of Sapap3-KO mice has been used as a model of obsessive-
compulsive disorder (OCD). Previous studies suggest that dysregulation of cortico-striatal …
compulsive disorder (OCD). Previous studies suggest that dysregulation of cortico-striatal …