IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity
M Gómez-Herranz, J Taylor, RD Sloan - Journal of Biological Chemistry, 2023 - ASBMB
Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
Mechanisms underlying structural variant formation in genomic disorders
With the recent burst of technological developments in genomics, and the clinical
implementation of genome-wide assays, our understanding of the molecular basis of …
implementation of genome-wide assays, our understanding of the molecular basis of …
[HTML][HTML] Resurrection of endogenous retroviruses during aging reinforces senescence
Whether and how certain transposable elements with viral origins, such as endogenous
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …
Human structural variation: mechanisms of chromosome rearrangements
Chromosome structural variation (SV) is a normal part of variation in the human genome, but
some classes of SV can cause neurodevelopmental disorders. Analysis of the DNA …
some classes of SV can cause neurodevelopmental disorders. Analysis of the DNA …
Genome mining shows that retroviruses are pervasively invading vertebrate genomes
Endogenous retroviruses (ERVs) record past retroviral infections, providing molecular
archives for interrogating the evolution of retroviruses and retrovirus-host interaction …
archives for interrogating the evolution of retroviruses and retrovirus-host interaction …
Transposable element-mediated rearrangements are prevalent in human genomes
Transposable elements constitute about half of human genomes, and their role in
generating human variation through retrotransposition is broadly studied and appreciated …
generating human variation through retrotransposition is broadly studied and appreciated …
Switching sides: how endogenous retroviruses protect us from viral infections
S Srinivasachar Badarinarayan, D Sauter - Journal of Virology, 2021 - Am Soc Microbiol
Long disregarded as junk DNA or genomic dark matter, endogenous retroviruses (ERVs)
have turned out to represent important components of the antiviral immune response. These …
have turned out to represent important components of the antiviral immune response. These …
Predicting human genes susceptible to genomic instability associated with Alu/Alu-mediated rearrangements
Alu elements, the short interspersed element numbering more than 1 million copies per
human genome, can mediate the formation of copy number variants (CNVs) between …
human genome, can mediate the formation of copy number variants (CNVs) between …
Exome sequencing and whole genome sequencing for the detection of copy number variation
JY Hehir-Kwa, R Pfundt, JA Veltman - Expert review of molecular …, 2015 - Taylor & Francis
Many laboratories now use genomic microarrays as their first-tier diagnostic test for copy
number variation (CNV) detection. In addition, whole exome sequencing is increasingly …
number variation (CNV) detection. In addition, whole exome sequencing is increasingly …
Molecular functions of human endogenous retroviruses in health and disease
M Suntsova, A Garazha, A Ivanova, D Kaminsky… - Cellular and Molecular …, 2015 - Springer
Human endogenous retroviruses (HERVs) and related genetic elements form 504 distinct
families and occupy~ 8% of human genome. Recent success of high-throughput …
families and occupy~ 8% of human genome. Recent success of high-throughput …