Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise
to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has …

Metastasis is the hallmark of failed tumor treatment and is typically associated with death
due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular …

Transient receptor potential vanilloid (TRPV) channel proteins belong to the superfamily of
TRP proteins that form cationic channels in the animal cell membranes. These proteins have …

Particulate matter (PM) is constituted by particles with sizes in the nanometer to micrometer
scales. PM can be generated from natural sources such as sandstorms and wildfires, and …

Chronic inflammation in the urinary bladder is a potential risk factor for bladder dysfunction,
including interstitial cystitis/bladder pain syndrome (IC/BPS). Although several studies have …

The transient receptor potential vanilloid type 4, TRPV4, is a polymodal cation channel
which can be activated by diverse stimuli including mechanical, thermal and chemical cues …

The bladder supports a diversity of macrophage populations with functional roles related to
homeostasis and host defense, including clearance of cell debris from tissue, immune …

The epithelial-to-mesenchymal transition (EMT) is a strictly regulated process that is
indispensable for normal development, but it can result in fibrosis and cancer progression. It …

By engaging in redox processes, ferroptosis plays a crucial role in sepsis-induced acute
lung injury (ALI). Although iron stimulates calcium signaling through the stimulation of redox …

Sepsis-associated acute kidney injury (S-AKI) is a frequent complication in patients who are
critically ill, which is often initiated by glomerular endothelial cell dysfunction. Although …