The development and application of multi-scale models of the lung has significantly
increased in recent years. These hybrid models merge realistic representations of the larger …

After shifting away from invasive mechanical ventilation and intratracheal instillation of
surfactant toward non-invasive ventilation with nasal CPAP and less invasive surfactant …

Pharmaceutical aerosol systems present a significant challenge to computational fluid
dynamics (CFD) modeling based on the need to capture multiple levels of turbulence …

In this work, the behavior of inhaled water droplets with initial sizes of 1–30 μm was studied
under a sinusoidal cyclic breathing pattern. The maximum flow rate was 15 L/min, and the …

The administration of surfactant aerosol therapy to preterm infants receiving continuous
positive airway pressure (CPAP) respiratory support is highly challenging due to small flow …

Nebulized lung surfactant therapy has been a neonatology long-pursued goal.
Nevertheless, many clinical trials have yet to show a clear clinical efficacy of nebulized …

The development of mesh nebulizer technology has expanded the ability to deliver medical
aerosols to infants and small children via nasal cannula and prongs. Mesh nebulizers do not …

Purpose To improve the quality of aerosol delivery to infants, the iDP-ADS was advanced to
include dual-prong nose-to-lung aerosol administration with a bifurcating interface …

Dry powder inhaler (DPI) is one of many pulmonary drug delivery systems that are
commonly prescribed for the treatment of a variety of diseases. However, the efficiency of the …

Microbubble ultrasound contrast agents have been used safely and effectively in diagnostic
applications for several decades. Although their use in the lungs has not been widely …