Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

Cardiovascular-kidney-metabolic health: a presidential advisory from the American Heart Association

CE Ndumele, J Rangaswami, SL Chow, IJ Neeland… - Circulation, 2023 - ahajournals.org
Cardiovascular-kidney-metabolic health reflects the interplay among metabolic risk factors,
chronic kidney disease, and the cardiovascular system and has profound impacts on …

A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis

SA Harrison, P Bedossa, CD Guy… - … England Journal of …, 2024 - Mass Medical Soc
Background Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with no
approved treatment. Resmetirom is an oral, liver-directed, thyroid hormone receptor beta …

Tirzepatide for metabolic dysfunction–associated steatohepatitis with liver fibrosis

R Loomba, ML Hartman, EJ Lawitz… - … England Journal of …, 2024 - Mass Medical Soc
Background Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive liver
disease associated with liver-related complications and death. The efficacy and safety of …

A phase 2 randomized trial of survodutide in MASH and fibrosis

AJ Sanyal, P Bedossa, M Fraessdorf… - … England Journal of …, 2024 - Mass Medical Soc
Background Dual agonism of glucagon receptor and glucagon-like peptide-1 (GLP-1)
receptor may be more effective than GLP-1 receptor agonism alone for treating metabolic …

Metabolic dysfunction-associated steatotic liver disease (MASLD): a state-of-the-art review

WK Chan, KH Chuah, RB Rajaram… - Journal of obesity & …, 2023 - pmc.ncbi.nlm.nih.gov
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the latest term for
steatotic liver disease associated with metabolic syndrome. MASLD is the most common …

MASLD: a systemic metabolic disorder with cardiovascular and malignant complications

G Targher, CD Byrne, H Tilg - Gut, 2024 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic
liver disease globally and is currently estimated to affect up to 38% of the global adult …

HIV infection

LG Bekker, C Beyrer, N Mgodi, SR Lewin… - Nature Reviews …, 2023 - nature.com
The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

Current status and future trends of the global burden of MASLD

L Miao, G Targher, CD Byrne, YY Cao… - Trends in Endocrinology & …, 2024 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most
common chronic liver disease globally, affecting more than a third of the world's adult …

A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American …

CE Ndumele, IJ Neeland, KR Tuttle, SL Chow… - Circulation, 2023 - ahajournals.org
A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors
such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led …