A rational use of clozapine based on adverse drug reactions, pharmacokinetics, and clinical pharmacopsychology

J de Leon, CJ Ruan, G Schoretsanitis… - Psychotherapy and …, 2020‏ - karger.com
Abstract Using Richardson and Davidson's model and the sciences of pharmacokinetics and
clinical pharmacopsychology, this article reviewed the:(1) poor life expectancy associated …

Clinical pharmacokinetics of atypical antipsychotics: an update

MC Mauri, S Paletta, C Di Pace, A Reggiori… - Clinical …, 2018‏ - Springer
Therapeutic drug monitoring studies have generally concentrated on controlling compliance
and avoiding side effects by maintaining long-term exposure to minimally effective blood …

[ספר][B] The American Psychiatric Association practice guideline for the treatment of patients with schizophrenia

American Psychiatric Association - 2020‏ - psychiatryonline.org
The goal of this guideline is to improve the quality of care and treatment outcomes for
patients with schizophrenia, as defined by the Diagnostic and Statistical Manual of Mental …

Association of CYP2C19 and CYP2D6 poor and intermediate metabolizer status with antidepressant and antipsychotic exposure: a systematic review and meta …

F Milosavljević, N Bukvić, Z Pavlović, Č Miljević… - JAMA …, 2021‏ - jamanetwork.com
Importance Precise estimation of the drug metabolism capacity for individual patients is
crucial for adequate dose personalization. Objective To quantify the difference in the …

Evidence-based guidelines for the pharmacological treatment of schizophrenia: updated recommendations from the British Association for Psychopharmacology

TRE Barnes, R Drake, C Paton… - Journal of …, 2020‏ - journals.sagepub.com
These updated guidelines from the British Association for Psychopharmacology replace the
original version published in 2011. They address the scope and targets of pharmacological …

Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical …

AF Pardiñas, DB Kappel, M Roberts, F Tipple… - The Lancet …, 2023‏ - thelancet.com
Background The antipsychotic, clozapine, is the only licensed drug against the treatment-
resistant symptoms that affect 20–30% of people with schizophrenia. Clozapine is markedly …

Antipsychotic treatment failure: a systematic review on risk factors and interventions for treatment adherence in psychosis

K El Abdellati, L De Picker, M Morrens - Frontiers in neuroscience, 2020‏ - frontiersin.org
Objective: Antipsychotic medication non-adherence has detrimental effects on patients'
clinical outcome. It is unclear which risk factors affect adherence most and which …

Clinical risk factors for the development of tardive dyskinesia

M Solmi, G Pigato, JM Kane, CU Correll - Journal of the Neurological …, 2018‏ - Elsevier
Background Tardive dyskinesia (TD) is a severe condition that can affect almost 1 out of 4
patients on current or previous antipsychotic treatment, including both first-generation …

Dopamine and glutamate in antipsychotic-responsive compared with antipsychotic-nonresponsive psychosis: a multicenter positron emission tomography and …

A Egerton, A Murphy, J Donocik, A Anton… - Schizophrenia …, 2021‏ - academic.oup.com
The variability in the response to antipsychotic medication in schizophrenia may reflect
between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies …

[HTML][HTML] Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre …

AP Morrison, M Pyle, D Maughan, L Johns… - The Lancet …, 2020‏ - thelancet.com
Background Evidence for the effectiveness of treatments in early-onset psychosis is sparse.
Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials …