Optimal control theory provides insight into complex resource allocation decisions. The
forward–backward sweep method (FBSM) is an iterative technique commonly implemented …

As modeling becomes a more widespread practice in the life sciences and biomedical
sciences, researchers need reliable tools to calibrate models against ever more complex …

The bone marrow microenvironment (BMM) plays a critical role in hematopoietic stem cells
(HSCs) maintenance and regulation. There is increasing interest in the role of the BMM in …

The hematopoietic stem cell (HSC) niche is a crucial driver of regeneration and malignancy.
Its interaction with hematopoietic and malignant stem cells is highly complex and direct …

Bone marrow niche is a major contributing factor in leukemia development and drug
resistance in acute myeloid leukemia (AML) patients. Although mimicking leukemic bone …

Chronic myeloid leukemia (CML) is a blood disease that disrupts normal function of the
hematopoietic system. Despite the great progress made in terms of molecular therapies for …

Acute myeloid leukaemia (AML) is a blood cancer affecting haematopoietic stem cells. AML
is routinely treated with chemotherapy, and so it is of great interest to develop optimal …

Stem cells are fundamental to human life and offer great therapeutic potential, yet their
biology remains incompletely—or in cases even poorly—understood. The field of stem cell …

Strategic management of populations of interacting biological species routinely requires
interventions combining multiple treatments or therapies. This is important in key research …

A mathematical model given by a two-dimensional differential system is introduced in order
to understand the transition process from the normal hematopoiesis to the chronic and …