A review: FDA-approved fluorine-containing small molecules from 2015 to 2022

N Sheikhi, M Bahraminejad, M Saeedi… - European Journal of …, 2023 - Elsevier
Fluorine-containing small molecules have occupied an especial position in drug discovery
research. The successful clinical use of fluorinated corticosteroids in the 1950s and …

Application of next generation sequencing for diagnosis and clinical management of drug-resistant tuberculosis: updates on recent developments in the field

N Dookie, A Khan, N Padayatchi, K Naidoo - Frontiers in Microbiology, 2022 - frontiersin.org
The World Health Organization's End TB Strategy prioritizes universal access to an early
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …

Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid

A Bateson, J Ortiz Canseco, TD McHugh… - Journal of …, 2022 - academic.oup.com
Objectives To develop a robust phenotypic antimicrobial susceptibility testing (AST) method
with a correctly set breakpoint for pretomanid (Pa), the most recently approved anti …

[BOOK][B] Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance

World Health Organization - 2023 - books.google.com
Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid

PJ Gómez-González, J Perdigao, P Gomes… - Scientific reports, 2021 - nature.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest infectious
diseases worldwide. Multidrug and extensively drug-resistant strains are making disease …

Profiling pretomanid as a therapeutic option for TB infection: evidence to date

SL Stancil, F Mirzayev… - Drug Design …, 2021 - Taylor & Francis
Tuberculosis (TB) is the most deadly infectious disease globally. Although most individuals
achieve a cure, a substantial portion develop multi-drug resistant TB which is exceedingly …

Delamanid or pretomanid? A Solomonic judgement!

SE Mudde, AM Upton, A Lenaerts, HI Bax… - Journal of …, 2022 - academic.oup.com
Given the low treatment success rates of drug-resistant tuberculosis (TB), novel TB drugs are
urgently needed. The landscape of TB treatment has changed considerably over the last …

Baseline and acquired resistance to bedaquiline, linezolid and pretomanid, and impact on treatment outcomes in four tuberculosis clinical trials containing pretomanid

J Timm, A Bateson, P Solanki, A Paleckyte… - PLOS Global Public …, 2023 - journals.plos.org
Bedaquiline (B), pretomanid (Pa) and linezolid (L) are key components of new regimens for
treating rifampicin-resistant tuberculosis (TB). However, there is limited information on the …

Fabrication of MoS2/Bi2S3 heterostructure for photocatalytic degradation of Metronidazole and Cefalexin and antibacterial applications under NIR light …

H Pasdar, N Elmi Fard, M Rezvani - Applied Physics A, 2023 - Springer
In this research, molybdenum disulfide (MoS2) and bismuth trisulfide (Bi2S3) particles were
synthesized. Bi2S3 was loaded on MoS2 nanosheet and was characterized by several …

[PDF][PDF] Optimized broth microdilution plate methodology for drug susceptibility testing of Mycobacterium tuberculosis complex

World Health Organization - 2022 - apps.who.int
Under the terms of this licence, you may copy, redistribute and adapt the work for non-
commercial purposes, provided the work is appropriately cited, as indicated below. In any …