Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …

Background: Despite an increasing body of research highlighting their efficacy to treat a
broad range of medical conditions, psychedelic drugs remain a controversial issue among …

Background Psilocybin may have antidepressant properties, but direct comparisons
between psilocybin and established treatments for depression are lacking. Methods In a …

Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …

Importance Major depressive disorder (MDD) is a substantial public health burden, but
current treatments have limited effectiveness and adherence. Recent evidence suggests that …

Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …

A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Background: Clinically significant anxiety and depression are common in patients with
cancer, and are associated with poor psychiatric and medical outcomes. Historical and …

Rationale Recent clinical trials are reporting marked improvements in mental health
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …