Pharmacological targeting of endoplasmic reticulum stress in disease
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …
Endoplasmic reticulum stress signals in the tumour and its microenvironment
Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …
regulated processes that determine cell function, fate and survival. In several tumour types …
Mechanisms, regulation and functions of the unfolded protein response
Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
The integrated stress response: From mechanism to disease
BACKGROUND The integrated stress response (ISR) is an evolutionarily conserved
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and
metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic …
metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic …
[HTML][HTML] Endoplasmic reticulum stress signaling in cancer cells
SA Oakes - The American journal of pathology, 2020 - Elsevier
To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …
Translational control of stem cell function
Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …
cell types. Research has focused primarily on how these processes are regulated at a …
Control of immune cell function by the unfolded protein response
Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …
synthesis, folding, modification and trafficking in leukocytes, which are processes …
ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance
Y Xu, P Huangyang, Y Wang, L Xue, E Devericks… - Cell, 2021 - cell.com
Estrogen receptor α (ERα) is a hormone receptor and key driver for over 70% of breast
cancers that has been studied for decades as a transcription factor. Unexpectedly, we …
cancers that has been studied for decades as a transcription factor. Unexpectedly, we …
Pharmacological targeting of the unfolded protein response for disease intervention
Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …
many human diseases including obesity, liver disorders, cancer, diabetes and …