The presence of thiols in living systems is critical for the maintenance of cellular redox
potentials and protein thiol-disulfide ratios, as well as for the protection of cells from reactive …

In Crithidia fasciculata the biosynthesis of trypanothione (N 1, N 8-bis (glutathionyl)
spermidine; reduced trypanothione), a redox mediator unique to and essential for …

Glutathione (GSH) forms conjugates with polyamines in prokaryotes and eukaryotes. There
is also evidence suggesting cross-talk between GSH and polyamines to regulate cellular …

* Address reprint requests to: Dr. Koei Hamana, School of Health Sciences, Faculty of
Medicine, Gunma University, Showa-machi, Maebashi, Gunma 371–8514, Japan. E-mail …

Polyamines are substances involved in many aspects of cell growth, division, and
differentiation. Because of the metabolic differences between host cells and parasite cells …

Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated
in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds …

A series of novel platinum (II) complexes derived from N-alkyl-ethanediamine and N-alkyl-
propanediamine ligands were prepared and characterized. These complexes contain a long …

The effects of insulin on the in vitro growth characteristics of Trypanosoma granulosum were
investigated. The insulin growth stimulus had a rapid onset with little or no lag phase but …

Polyamines are substances involved in many aspects of cell growth, division, and
differentiation. Because of the metabolic differences between host cells and parasite cells …