WNT proteins are secreted morphogens that are required for basic developmental
processes, such as cell-fate specification, progenitor-cell proliferation and the control of …

Abstract PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected
lymphoproliferations has largely been standardized and has consequently become …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …

T cell development in the mouse thymus has been studied extensively, but less is known
regarding T cell development in the human thymus. We used a combination of single-cell …

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal
overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non …

X-linked SCID (SCID-X1) is amenable to correction by gene therapy using conventional
gammaretroviral vectors. Here, we describe the occurrence of clonal T cell acute …

Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …

Acute lymphoblastic leukemia (ALL) is a hematopoietic malignancy derived from immature B-
lymphoid and T-lymphoid cells (T-ALL). In T-ALL, there is an early T-cell progenitor (ETP) …

To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we
combined expression profiling of 117 pediatric patient samples and detailed molecular …

During postnatal life, thymopoiesis depends on the continuous colonization of the thymus by
bone-marrow-derived hematopoietic progenitors that migrate through the bloodstream. The …