The evolution of insect biodiversity
Insects comprise over half of all described animal species. Together with the Protura
(coneheads), Collembola (springtails) and Diplura (two-pronged bristletails), insects form …
(coneheads), Collembola (springtails) and Diplura (two-pronged bristletails), insects form …
The mechanisms of substrate selection, catalysis, and translocation by the elongating RNA polymerase
Multi-subunit DNA-dependent RNA polymerases synthesize all classes of cellular RNAs,
ranging from short regulatory transcripts to gigantic messenger RNAs. RNA polymerase has …
ranging from short regulatory transcripts to gigantic messenger RNAs. RNA polymerase has …
Trigger loop of RNA polymerase is a positional, not acid–base, catalyst for both transcription and proofreading
The active site of multisubunit RNA polymerases (RNAPs) is highly conserved from humans
to bacteria. This single site catalyzes both nucleotide addition required for RNA transcript …
to bacteria. This single site catalyzes both nucleotide addition required for RNA transcript …
Dual Role of a (p) ppGpp‐and (p) ppApp‐degrading Enzyme in Biofilm Formation and Interbacterial Antagonism
The guanosine nucleotide‐based second messengers ppGpp and pppGpp (collectively:(p)
ppGpp) enable adaptation of microorganisms to environmental changes and stress …
ppGpp) enable adaptation of microorganisms to environmental changes and stress …
High-resolution phenotypic landscape of the RNA polymerase II trigger loop
The active sites of multisubunit RNA polymerases have a “trigger loop”(TL) that multitasks in
substrate selection, catalysis, and translocation. To dissect the Saccharomyces cerevisiae …
substrate selection, catalysis, and translocation. To dissect the Saccharomyces cerevisiae …
Two distinct pathways of RNA polymerase backtracking determine the requirement for the Trigger Loop during RNA hydrolysis
Transcribing RNA polymerase (RNAP) can fall into backtracking, phenomenon when the 3′
end of the transcript disengages from the template DNA. Backtracking is caused by …
end of the transcript disengages from the template DNA. Backtracking is caused by …
[HTML][HTML] Transcription fidelity and its roles in the cell
P Gamba, N Zenkin - Current Opinion in Microbiology, 2018 - Elsevier
Highlights•The Trigger Loop is one of the major determinants of transcription fidelity.•Intrinsic
proofreading occurs via transcript-assisted cleavage.•Factor-assisted proofreading takes …
proofreading occurs via transcript-assisted cleavage.•Factor-assisted proofreading takes …
Distinct effects of DNA lesions on RNA synthesis by Escherichia coli RNA polymerase
D Pupov, A Ignatov, A Agapov… - … and Biophysical Research …, 2019 - Elsevier
DNA lesions can severely compromise genome stability and lead to cell death if unrepaired.
RNA polymerase (RNAP) is known to serve as a sensor of DNA damage and to attract DNA …
RNA polymerase (RNAP) is known to serve as a sensor of DNA damage and to attract DNA …
Controller protein of restriction–modification system Kpn2I affects transcription of its gene by acting as a transcription elongation roadblock
E Klimuk, E Bogdanova, M Nagornykh… - Nucleic acids …, 2018 - academic.oup.com
C-proteins control restriction–modification (R–M) systems' genes transcription to ensure
sufficient levels of restriction endonuclease to allow protection from foreign DNA while …
sufficient levels of restriction endonuclease to allow protection from foreign DNA while …
[HTML][HTML] Kinetic Features of Degradation of R-Loops by RNase H1 from Escherichia coli
AA Kuznetsova, IA Kosarev, NA Timofeyeva… - International Journal of …, 2024 - mdpi.com
R-loops can act as replication fork barriers, creating transcription–replication collisions and
inducing replication stress by arresting DNA synthesis, thereby possibly causing aberrant …
inducing replication stress by arresting DNA synthesis, thereby possibly causing aberrant …