The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is
known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of …

Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …

Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal
(HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors …

Background Pubertal timing is known to be influenced by interactions among various
genetic, nutritional, environmental and socio-economic factors, although the ultimate …

The Notch signaling pathway is highly conserved during evolution. It has been well
documented that Notch signaling regulates cell proliferation, migration, and death in the …

The genetic disorders contributing to either delayed or precocious puberty demonstrate the
highly complex role of genetics in the regulation of puberty. There are numerous genetic …

Abstract Context and Objective This case control study was designed to investigate the
association between mutation of 10 single nucleotide polymorphism (SNP) loci (rs1132506 …

Mutations of MKRN3, the gene encoding makorin RING-finger protein 3, lead to central
precocious puberty (CPP). The aim of this study was to investigate mutations of the MKRN3 …

It is widely acknowledged that kisspeptin and its receptor Kiss1R play central regulatory
roles in the hypothalamus-pituitary-gonad (HPG) axis and reproduction. Mutations of KISS1 …