Background Endotheliopathy and coagulopathy appear to be the main causes for critical
illness and death in patients with coronavirus disease 2019 (COVID-19). The adhesive …

The von Willebrand factor (VWF) collagen binding (VWF: CB) assay was first reported for
use in von Willebrand diagnostics in 1986, by Brown and Bosak. Since then, the VWF: CB …

Extracellular vesicles (EVs) participate in cell-to-cell communication and contribute toward
homeostasis under physiological conditions. But EVs can also contribute toward a wide …

Objective: Advanced mass spectrometry methods were leveraged to analyze both
proteomics and metabolomics signatures in plasma upon controlled tissue injury (TI) and …

An increased concentration of palmitate in circulation is one of the most harmful factors in
obesity. The von Willebrand factor (vWF), a protein involved in haemostasis, is produced …

2021 and the COVID 19 pandemic have brought unprecedented blood shortages
worldwide. These deficits have propelled national efforts to reduce blood usage, including …

Background: Assessing simultaneous generation of thrombin (TG) and plasmin (PG) is an
approach to evaluate the balance between coagulation and fibrinolysis with sensitivity to …

Weight bias and stigma have limited the awareness of the systemic consequences related to
obesity. As the narrative evolves, obesity is emerging as a driver and enhancer of many …

Obesity and low enzyme A disintegrin and metalloproteinase with thrombospondin type-1
motif-13 (ADAMTS13) activity have been linked to poor coronavirus disease 2019 (COVID …

Laboratory derived, calculated parameters are ubiquitous and support clinical decision
making throughout medicine. In doing so, they present measurands as inputs to a new …