Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections
AG Toledo, E Bratanis, E Velásquez… - Nature …, 2023 - nature.com
Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and
systemic infections in humans. The molecular mechanisms that contribute to disease …
systemic infections in humans. The molecular mechanisms that contribute to disease …
SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions
Q Liu, BM Stadtmueller - Nature communications, 2023 - nature.com
Immunoglobulin (Ig) A functions as monomeric IgA in the serum and Secretory (S) IgA in
mucosal secretions. Host IgA Fc receptors (FcαRs), including human FcαR1/CD89, mediate …
mucosal secretions. Host IgA Fc receptors (FcαRs), including human FcαR1/CD89, mediate …
Host-microbiome protein-protein interactions capture disease-relevant pathways
Background Host-microbe interactions are crucial for normal physiological and immune
system development and are implicated in a variety of diseases, including inflammatory …
system development and are implicated in a variety of diseases, including inflammatory …
Global view of candidate therapeutic target genes in hormone-responsive breast cancer
Breast cancer (BC) is a heterogeneous disease characterized by different biopathological
features, differential response to therapy and substantial variability in long-term-survival. BC …
features, differential response to therapy and substantial variability in long-term-survival. BC …
IdeS, a secreted proteinase of Streptococcus pyogenes, is bound to a nuclease at the bacterial surface where it inactivates opsonizing IgG antibodies
IM Frick, L Happonen, S Wrighton, P Nordenfelt… - Journal of Biological …, 2023 - ASBMB
The important bacterial pathogen Streptococcus pyogenes secretes IdeS (immunoglobulin
G-degrading enzyme of S. pyogenes), a proteinase that cleaves human immunoglobulin G …
G-degrading enzyme of S. pyogenes), a proteinase that cleaves human immunoglobulin G …
Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O
D Tang, C Gueto-Tettay, E Hjortswang… - Analytical …, 2024 - ACS Publications
An important element of antibody-guided vaccine design is the use of neutralizing or
opsonic monoclonal antibodies to define protective epitopes in their native three …
opsonic monoclonal antibodies to define protective epitopes in their native three …
The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies
Streptococcus pyogenes can cause invasive disease with high mortality despite adequate
antibiotic treatments. To address this unmet need, we have previously generated an opsonic …
antibiotic treatments. To address this unmet need, we have previously generated an opsonic …
Dissecting Streptococcus pyogenes interaction with human
M Ijaz, F Ameen, YA Alfoteih, S Shamim… - Archives of …, 2020 - Springer
Streptococcus pyogenes is a species of Gram-positive bacteria. It is also known as Group A
Streptococcus (GAS) that causes pathogenesis to humans only. The GAS infection has …
Streptococcus (GAS) that causes pathogenesis to humans only. The GAS infection has …
Epidemiological analysis of Group A streptococcus infection diseases among children in Bei**g, China under COVID-19 pandemic
H Li, L Zhou, Y Zhao, L Ma, H Zhang, Y Liu, X Liu, J Hu - BMC pediatrics, 2023 - Springer
Background Group A streptococcus is human-restricted gram-positive pathogen,
responsible for various clinical presentations from mild epidermis infections to life …
responsible for various clinical presentations from mild epidermis infections to life …
Streptolysin O accelerates the conversion of plasminogen to plasmin
Abstract Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can
exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its …
exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its …