An overview of comet assay application for detecting DNA damage in aquatic animals

N Jiang, S Naz, Y Ma, Q Ullah, MZ Khan, J Wang, X Lu… - Agriculture, 2023 - mdpi.com
This review discusses several research studies that employed comet assay to evaluate the
environmental impact of genotoxins in aquatic environments. It focuses on in vivo and in situ …

The comet assay in animal models: From bugs to whales–(Part 1 Invertebrates)

G Gajski, B Žegura, C Ladeira, B Pourrut… - … Research/Reviews in …, 2019 - Elsevier
The comet assay, also called single cell gel electrophoresis, is a sensitive, rapid and low-
cost technique for quantifying and analysing DNA damage and repair at the level of …

Tailoring radiotherapies and nanotechnology for targeted treatment of solid tumors

MI Khan, F Batool, R Ali, W Wang, S Li, G Wang… - Coordination Chemistry …, 2022 - Elsevier
Existing anticancer therapeutic modalities in clinical settings lack efficacy and fail to
completely cure cancers. Clearly understandable and mechanistic approaches are …

Bioaccumulation of trace metals and total petroleum and genotoxicity responses in an edible fish population as indicators of marine pollution

A D'Costa, SK Shyama, MKP Kumar - Ecotoxicology and environmental …, 2017 - Elsevier
The present study reports the genetic damage and the concentrations of trace metals and
total petroleum hydrocarbons prevailing in natural populations of an edible fish, Arius arius …

Induction of DNA damage in the peripheral blood of zebrafish (Danio rerio) by an agricultural organophosphate pesticide, monocrotophos

AH D'Costa, SK Shyama, MK Praveen Kumar… - International Aquatic …, 2018 - Springer
The use of organophosphate pesticides (OPs) in agricultural practices in India has gained
popularity due to their broad spectrum, low cost and high potency. Monocrotophos (an OP) …

[HTML][HTML] DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of …

Y Wang, B Wei, D Wang, J Wu, J Gao, H Zhong… - … Pharmaceutica Sinica B, 2022 - Elsevier
Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic
agent irinotecan (CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has …

SSRP1 cooperates with PARP and XRCC1 to facilitate single-strand DNA break repair by chromatin priming

Y Gao, C Li, L Wei, Y Teng, S Nakajima, X Chen, J Xu… - Cancer research, 2017 - AACR
DNA single-strand breaks (SSB) are the most common form of DNA damage, requiring
repair processes that to initiate must overcome chromatin barriers. The FACT complex …

In vivo genotoxicity and cytotoxicity assessment of cadmium chloride in peripheral erythrocytes of Labeo rohita (Hamilton)

R **dal, S Verma - Ecotoxicology and Environmental safety, 2015 - Elsevier
Cadmium chloride (CdCl 2) induced genotoxicity and cytotoxicity has been assessed in the
peripheral blood erythrocytes of freshwater fish Labeo rohita exposed to 0.37 and 0.62 mg/L …

Mechanism-Based Sonodynamic–Chemo Combinations against Triple-Negative Breast Cancer

X Feng, C Wu, W Yang, J Wu, P Wang - International journal of molecular …, 2022 - mdpi.com
Due to its noninvasive nature, site-confined irradiation, and high tissue penetrating
capabilities, ultrasound (US)-driven sonodynamic treatment (SDT) has been proven to have …

Effects of pollution on marine organisms

AJ Mearns, DJ Reish, PS Oshida, T Ginn… - Water Environment …, 2015 - Wiley Online Library
This review covers selected 2014 articles on the biological effects of pollutants and human
physical disturbances on marine and estuarine plants, animals, ecosystems and habitats …