Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Objective: In schizophrenia, somatostatin (SST) and parvalbumin (PV) mRNA levels are
lower in the dorsolateral prefrontal cortex (DLPFC), but it remains unclear whether these …

A growing body of evidence has emerged demonstrating a pathological link between
oxidative stress and schizophrenia. This evidence identifies oxidative stress as a …

Dopamine is required for working memory, but how it modulates the large-scale cortex is
unknown. Here, we report that dopamine receptor density per neuron, measured by …

Schizophrenia is associated with disrupted cognitive control and sleep-wake cycles. Here
we identify diurnal rhythms in gene expression in the human dorsolateral prefrontal cortex …

Converging evidence implicates redox dysregulation as a pathological mechanism driving
the emergence of psychosis. Increased oxidative damage and decreased capacity of …

Dysfunction of the cortical dorsal visual stream and visuospatial working memory (vsWM)
network in individuals with schizophrenia (SZ) likely reflects alterations in both excitatory …

Alterations in neocortical GABAergic interneurons (INs) have been affiliated with
neuropsychiatric diseases, including schizophrenia (SZ). Significant progress has been …

Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent
findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest …