Landomycin biosynthesis and its regulation in Streptomyces

O Yushchuk, M Kharel, I Ostash, B Ostash - Applied Microbiology and …, 2019 - Springer
This mini-review is centered on genetic aspects of biosynthesis of landomycins (La), a family
of angucycline polyketides. From the very discovery in the 1990s, La were noted for unusual …

Himalaquinones A–G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate Streptomyces sp. PU-MM59

Y Zhang, MT Cheema, LV Ponomareva… - Journal of natural …, 2021 - ACS Publications
Himalaquinones A–G, seven new anthraquinone-derived metabolites, were obtained from
the Himalayan-based Streptomyces sp. PU-MM59. The chemical structures of the new …

Heterologous AdpA transcription factors enhance landomycin production in Streptomyces cyanogenus S136 under a broad range of growth conditions

O Yushchuk, I Ostash, I Vlasiuk, T Gren… - Applied Microbiology …, 2018 - Springer
Streptomyces cyanogenus S136 is the only known producer of landomycin A (LaA), one of
the largest glycosylated angucycline antibiotics possessing strong antiproliferative …

[HTML][HTML] Whole genome analysis of Streptomyces sp. RerS4, a Rehmannia glutinosa rhizosphere microbe producing a new lipopeptide

H He, J Huang, Z Zhao, P Du, J Li, J **n, H Xu, W Feng… - Heliyon, 2023 - cell.com
Rehmannia glutinosa, a valuable medicinal plant, is threatened by ring rot, a condition that
greatly affects its yield and quality. Interactions between plant and the rhizosphere soil …

The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK

A Tsugita, S Uehara, T Matsui, T Yokoyama… - The FEBS …, 2022 - Wiley Online Library
Landomycin A (LaA) is the largest member of the landomycin group of angucyclic
polyketides. Its unusual structure and strong anticancer properties have attracted great …

Study of the complexation between Landomycin A and C 60 fullerene in aqueous solution

YI Prylutskyy, VV Cherepanov, VV Kostjukov… - RSC Advances, 2016 - pubs.rsc.org
We report here the first investigation of the non-covalent complexation between C60
fullerene and angucycline antibiotic Landomycin A. By means of various physico-chemical …

A general strategy for diverse syntheses of anhydrolandomycinone, tetrangulol, and landomycinone

CJ Sie, V Patteti, YR Yang, KKT Mong - Chemical Communications, 2018 - pubs.rsc.org
A general strategy for diverse syntheses of anhydrolandomycinone, tetrangulol, and
landomycinone - Chemical Communications (RSC Publishing) DOI:10.1039/C7CC09818A …

Rapid spectrophotometric detection for optimized production of landomycins and characterization of their therapeutic potential

TC Chappell, KG Maiello, AJ Tierney… - Biotechnology and …, 2024 - Wiley Online Library
Microbial‐derived natural products remain a major source of structurally diverse bioactive
compounds and chemical scaffolds that have the potential as new therapeutics to target …

Self-Organization of Pristine C60 Fullerene and its Complexes with Chemotherapy Drugs in Aqueous Solution as Promising Anticancer Agents

LA Bulavin, Y Prylutskyy, O Kyzyma… - Modern Problems of …, 2018 - Springer
The self-organization of pristine C 60 fullerene and its complexation with chemotherapy
drugs (in particular, doxorubicin, cisplatin and landomycin A) in aqueous solution were …

САМОАССОЦИАЦИЯ ФУЛЛЕРЕНА И ЕГО КОМПЛЕКСООБРАЗОВАНИЕ С ХИМИОТЕРАПЕВТИЧЕСКИМИ ПРЕПАРАТАМИ-ПЕРСПЕКТИВНОЕ …

АА Мосунов, ВА Сало, ДП Воронин… - … физики и химии, 2019 - elibrary.ru
Самоассоциация немодифицированного фуллерена С 60 и его комплексообразование
с химиотерапевтическими препаратами (в частности, доксорубицином, цисплатином и …