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AMP-activated protein kinase signaling in metabolic regulation
YC Long, JR Zierath - The Journal of clinical investigation, 2006 - jci.org
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake …
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake …
Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery
L Tong - Cellular and Molecular Life Sciences CMLS, 2005 - Springer
Acetyl-coenzyme A carboxylases (ACCs) have crucial roles in fatty acid metabolism in most
living organisms. Mice deficient in ACC2 have continuous fatty acid oxidation and reduced …
living organisms. Mice deficient in ACC2 have continuous fatty acid oxidation and reduced …
Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS)
M Ristow, K Schmeisser - Dose-response, 2014 - journals.sagepub.com
Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw, M Kosmatka, N Bardeesy, RL Hurley… - Proceedings of the …, 2004 - pnas.org
AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status
found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP …
found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP …
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw, N Bardeesy, BD Manning, L Lopez… - Cancer cell, 2004 - cell.com
Germline mutations in LKB1, TSC2, or PTEN tumor suppressor genes result in
hamartomatous syndromes with shared tumor biological features. The recent observations …
hamartomatous syndromes with shared tumor biological features. The recent observations …
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
OM Palacios, JJ Carmona, S Michan… - Aging (albany …, 2009 - pmc.ncbi.nlm.nih.gov
SIRT3 is a member of the sirtuin family of NAD+-dependent deacetylases, which is localized
to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other …
to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other …
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
RR Russell, J Li, DL Coven, M Pypaert… - The Journal of clinical …, 2004 - jci.org
AMP-activated protein kinase (AMPK) is an important regulator of diverse cellular pathways
in the setting of energetic stress. Whether AMPK plays a critical role in the metabolic and …
in the setting of energetic stress. Whether AMPK plays a critical role in the metabolic and …
The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
The receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 play important
roles in necroptosis that are closely linked to the inflammatory response. Although the …
roles in necroptosis that are closely linked to the inflammatory response. Although the …
Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model
H Baek, null Sanjay, M Park, HJ Lee - Journal of Neuroinflammation, 2023 - Springer
Abstract Cyanidin-3-O-glucoside (C3G) is a natural anthocyanin with antioxidant, anti-
inflammatory, and antitumor properties. However, as the effects of C3G on the …
inflammatory, and antitumor properties. However, as the effects of C3G on the …
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
SP Hong, FC Leiper, A Woods, D Carling… - Proceedings of the …, 2003 - pnas.org
The Snf1/AMP-activated protein kinase (AMPK) family plays fundamental roles in cellular
responses to metabolic stress in eukaryotes. In humans, AMPK regulates lipid and glucose …
responses to metabolic stress in eukaryotes. In humans, AMPK regulates lipid and glucose …