The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors

G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …

Mechanistic understanding of curcumin's therapeutic effects in lung cancer

WNB Wan Mohd Tajuddin, NH Lajis, F Abas, I Othman… - Nutrients, 2019 - mdpi.com
Lung cancer is among the most common cancers with a high mortality rate worldwide.
Despite the significant advances in diagnostic and therapeutic approaches, lung cancer …

Metabolic reprogramming in breast cancer results in distinct mitochondrial bioenergetics between luminal and basal subtypes

P Lunetti, M Di Giacomo, D Vergara… - The FEBS …, 2019 - Wiley Online Library
Mitochondrial dysfunction is a key feature of cancer and is frequently associated with
increased aggressiveness and metastatic potential. Recent evidence has brought to light a …

Unraveling the anticancer effect of curcumin and resveratrol

AR Pavan, GDB Silva, DH Jornada, DE Chiba… - Nutrients, 2016 - mdpi.com
Resveratrol and curcumin are natural products with important therapeutic properties useful
to treat several human diseases, including cancer. In the last years, the number of studies …

The cancer microbiota: EMT and inflammation as shared molecular mechanisms associated with plasticity and progression

D Vergara, P Simeone, M Damato, M Maffia… - Journal of …, 2019 - Wiley Online Library
With the advent of novel molecular platforms for high‐throughput/next‐generation
sequencing, the communities of commensal and pathogenic microorganisms that inhabit the …

Proteomics-based identification of dysregulated proteins in breast cancer

AN Neagu, M Jayathirtha, D Whitham, P Mutsengi… - Proteomes, 2022 - mdpi.com
Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …

Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) Is upregulated in breast epithelial–mesenchymal transition and responds to oxidative stress

Q Wang, ST Karvelsson, A Kotronoulas… - Molecular & Cellular …, 2022 - ASBMB
Breast cancer cells that have undergone partial epithelial–mesenchymal transition (EMT)
are believed to be more invasive than cells that have completed EMT. To study metabolic …

Anti-metastatic effect of pyruvate dehydrogenase kinase 4 inhibition in bladder Cancer via the ERK, SRC, and JNK pathways

EH Lee, JW Chung, E Sung, BH Yoon, M Jeon… - International Journal of …, 2022 - mdpi.com
Bladder cancer is a common global cancer with a high percentage of metastases and high
mortality rate. Thus, it is necessary to identify new biomarkers that can be helpful in …

Epithelial–Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review

R González-González, G Ortiz-Sarabia… - Cancers, 2021 - mdpi.com
Simple Summary Mesenchymal conversion occurring in malignant epithelial neoplasms is
undesirable in tumors since it promotes more aggressive tumor behavior. This phenomenon …

[HTML][HTML] Translating epithelial mesenchymal transition markers into the clinic: Novel insights from proteomics

D Vergara, P Simeone, J Franck, M Trerotola… - EuPA Open …, 2016 - Elsevier
The growing understanding of the molecular mechanisms underlying epithelial-to-
mesenchymal transition (EMT) may represent a potential source of clinical markers. Despite …