Use of molecular docking computational tools in drug discovery
Molecular docking has become an important component of the drug discovery process.
Since first being developed in the 1980s, advancements in the power of computer hardware …
Since first being developed in the 1980s, advancements in the power of computer hardware …
Synthesis and pharmacological activities of pyrazole derivatives: A review
Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …
that possesses almost all types of pharmacological activities. The presence of this nucleus in …
Design and synthesis of novel antimicrobial agents
Z Breijyeh, R Karaman - Antibiotics, 2023 - mdpi.com
The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …
Recent advances of pyrazole-containing derivatives as anti-tubercular agents
Z Xu, C Gao, QC Ren, XF Song, LS Feng… - European journal of …, 2017 - Elsevier
One-third of the world's population infected tuberculosis (TB), and more than 1 million
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …
Linkers in fragment-based drug design: an overview of the literature
D Grenier, S Audebert, J Preto… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction In fragment-based drug design, fragment linking is a popular strategy where two
fragments binding to different sub-pockets of a target are linked together. This attractive …
fragments binding to different sub-pockets of a target are linked together. This attractive …
Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)
Infectious diseases remain a significant threat to human health, contributing to more than 17
million deaths, annually. With the worsening trends of drug resistance, there is a need for …
million deaths, annually. With the worsening trends of drug resistance, there is a need for …
Intrinsic antibacterial activity of nanoparticles made of β-cyclodextrins potentiates their effect as drug nanocarriers against tuberculosis
Multi-drug-resistant tuberculosis (TB) is a major public health problem, concerning about
half a million cases each year. Patients hardly adhere to the current strict treatment …
half a million cases each year. Patients hardly adhere to the current strict treatment …
Novel linezolid-based oxazolidinones as potent anticandidiasis and antitubercular agents
The quest for new antifungal and antitubercular drugs is a need of the hour because of
morbid co-pathogenesis and an increase in immunocompromised patients. One of the ways …
morbid co-pathogenesis and an increase in immunocompromised patients. One of the ways …
Recent trends in fragment-based anticancer drug design strategies against different targets: A mini-review
Cancer is a rapidly growing disease in modern society. Chemotherapy is the first choice for
cancer treatment. Design and development of new chemotherapeutic drugs by targeting …
cancer treatment. Design and development of new chemotherapeutic drugs by targeting …
Map** major SARS-CoV-2 drug targets and assessment of druggability using computational fragment screening: Identification of an allosteric small-molecule …
MR Freidel, RS Armen - PLoS One, 2021 - journals.plos.org
The 2019 emergence of, SARS-CoV-2 has tragically taken an immense toll on human life
and far reaching impacts on society. There is a need to identify effective antivirals with …
and far reaching impacts on society. There is a need to identify effective antivirals with …