The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across
species, expressed across cell types, and active against a large proportion of the …

A great hallmark of breast cancer is the absence or presence of estrogen receptors ERα and
ERβ, with a dominant role in cell proliferation, differentiation and cancer progression. Both …

High-grade serous ovarian cancer (HG-SOC)—often referred to as a “silent killer”—is the
most lethal gynecological malignancy. The fallopian tube (murine oviduct) and ovarian …

The non-histone chromatin-binding protein HMGA2 is expressed predominantly in the
mesenchyme before its differentiation, but it is also expressed in tumors of epithelial origin …

Radiofrequency heat ablation is an ideal radical treatment for hepatocellular carcinoma
(HCC). However, insufficient radiofrequency ablation (IRFA) could lead to high recurrence of …

Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic
development and postnatal tissue homeostasis. TGFβ signalling regulates several biological …

Purpose: Chemoresistance is the main cause of treatment failure in cancer and is
associated with distant metastases and epithelial-to-mesenchymal transition (EMT). This …

The long noncoding RNA highly up-regulated in liver cancer (HULC) is aberrantly elevated
in hepatocellular carcinoma (HCC), and this up-regulation is crucial for HCC pathogenesis …

Ovarian cancer is one of the top gynecological malignancies that cause deaths among
females in the United States. At the molecular level, significant progress has been made in …