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[HTML][HTML] Colon cancer: from epidemiology to prevention
Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a
complex genetic and environmental aetiology. Unlike cancers with known environmental …
complex genetic and environmental aetiology. Unlike cancers with known environmental …
Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis
Tumor necrosis factor (TNF)‐α is a highly conserved proinflammatory cytokine with important
functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the …
functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the …
Inter-cell type interactions that control JNK signaling in the Drosophila intestine
JNK signaling is a critical regulator of inflammation and regeneration, but how it is controlled
in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine …
in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine …
Tissue homeostasis and non-homeostasis: from cell life cycles to organ states
Although tissue homeostasis—the steady state—implies stability, our organs are in a state of
continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically …
continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically …
The roles of the gut microbiota and chronic low-grade inflammation in older adults with frailty
YS Xu, XJ Liu, XX Liu, D Chen, MM Wang… - Frontiers in Cellular …, 2021 - frontiersin.org
Frailty is a major public issue that affects the physical health and quality of life of older
adults, especially as the population ages. Chronic low-grade inflammation has been …
adults, especially as the population ages. Chronic low-grade inflammation has been …
The Drosophila tumor necrosis factor receptor, Wengen, couples energy expenditure with gut immunity
It is well established that tumor necrosis factor (TNF) plays an instrumental role in
orchestrating the metabolic disorders associated with late stages of cancers. However, it is …
orchestrating the metabolic disorders associated with late stages of cancers. However, it is …
Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size
The gut is the primary interface between an animal and food, but how it adapts to qualitative
dietary variation is poorly defined. We find that the Drosophila midgut plastically resizes …
dietary variation is poorly defined. We find that the Drosophila midgut plastically resizes …
Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation
The adult intestine is a regionalized organ, whose size and cellular composition are
adjusted in response to nutrient status. This involves dynamic regulation of intestinal stem …
adjusted in response to nutrient status. This involves dynamic regulation of intestinal stem …
[HTML][HTML] Biotin controls intestinal stem cell mitosis and host-microbiome interactions
Diet is a key regulator of metabolism and interacts with the intestinal microbiome. Here, we
study the role of the Drosophila intestinal stem cell (ISC)-specific biotin transporter Smvt in …
study the role of the Drosophila intestinal stem cell (ISC)-specific biotin transporter Smvt in …
Intestinal Immune Deficiency and Juvenile Hormone Signaling Mediate a Metabolic Trade-off in Adult Drosophila Females
A trade-off hypothesis pertains to the biased allocation of limited resources between two of
the most important fitness traits, reproduction and survival to infection. This quid pro quo …
the most important fitness traits, reproduction and survival to infection. This quid pro quo …