The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as
a critical regulator of many physiological and pathophysiological processes, including …

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions …

▪ Abstract The high affinity receptor for immunoglobulin E (designated FcϵRI) is the member
of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific …

▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …

The potent lipid mediator sphingosine-1-phosphate (S1P) regulates diverse physiological
processes by binding to 5 specific GPCRs, although it also has intracellular targets. Here …

Sphingosine-1-phosphate (SPP) has diverse biological functions acting inside cells as a
second messenger to regulate proliferation and survival, and extracellularly, as a ligand for …

The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-
phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and …

Abstract S phingosine-1-phosphate (S1P) is a bioactive lipid mediator with crucial roles in a
wide variety of cellular functions across a broad range of organisms. Though a simple …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

Sphingolipide have been implicated in the regulation of cell growth, differentiation, and
programmed cell death. The current paradigm for their action is that complex sphingolipids …