This review serves to document advances in the synthesis, versatile bonding, and reactivity
of molecular main group metal hydrides within Groups 1, 2, and 12–16. Particular attention …

Conspectus The widespread presence of hydrocarbons makes C–H functionalization an
attractive alternative to traditional cross-coupling methods. As indole is an important …

The functionalization of C–H bonds in organic molecules containing functional groups has
been one of the holy grails of catalysis. One synthetically important approach to the diverse …

Organosilanes are of vital importance for modern human society, having found widespread
applications in functional materials, organic synthesis, drug discovery and life sciences …

This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …

The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

Enzymes that catalyze carbon–silicon bond formation are unknown in nature, despite the
natural abundance of both elements. Such enzymes would expand the catalytic repertoire of …

Recent advances in transition metal-catalyzed C–H bond functionalization have profoundly
impacted synthetic strategy. Since organic substrates typically contain several chemically …

In order to optimize a lead molecule for further development, bioisosteric replacements are
generally adopted as one of the strategies. Silicon appears to be the right choice as a …

C− H functionalization represents a paradigm shift from the standard logic of organic
synthesis. Instead of focusing on orchestration of selective reactions at functional groups, the …