Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …

Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Photothermal therapy (PTT) normally requires to maintain the temperature of tumor lesions
above 50° C, which potentially induces local inflammation and tumor metastasis. To avoid …

Pyran is an oxygen-containing heterocyclic moiety, which exhibits an array of
pharmacological properties. Pyran is also one of the important structural subunits found …

In all organisms, heat-shock proteins (HSPs) provide an ancient defense system. These
proteins act as molecular chaperones by assisting proper folding and refolding of misfolded …

Introduction• Main HSPs• HSPs, cell signalling and apoptosis‐HSPs' targets in upstream
signalling pathways‐HSPs' targets at the mitochondrial level‐HSPs' targets at the post …

The multifunctional, stress-inducible molecular chaperone HSP70 has important roles in
aiding protein folding and maintaining protein homeostasis. HSP70 expression is elevated …

Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their
rapid and abundant induction by stress. HSP genes are activated at the transcriptional level …

Pancreatic cancer is one of the most lethal human malignancies with an all-stage 5-year
survival frequency of< 5%, which highlights the urgent need for more effective therapeutic …

Tumor hypoxia is a major cause of failure in cancer therapy, and there is almost no
efficacious treatment for hypoxic tumors. Herein, an azo‐containing polymer (P2) is …