The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Multimodal fusion in neuroimaging combines data from multiple imaging modalities to
overcome the fundamental limitations of individual modalities. Neuroimaging fusion can …

Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …

Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in
extent between patients. It is unclear whether inter-individual variability in glutamate is …

Impairment of insulin action and metabolic dysregulation have traditionally been associated
with schizophrenia, although the molecular basis of such association remains still elusive …

The variability in the response to antipsychotic medication in schizophrenia may reflect
between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies …

Glutamatergic and GABAergic dysfunction are implicated in the pathophysiology of
schizophrenia. Previous work has shown relationships between glutamate, GABA, and brain …