Polycyclic aromatic hydrocarbon and its effects on human health: An overeview

MA Mallah, L Changxing, MA Mallah, S Noreen, Y Liu… - Chemosphere, 2022 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable
environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen …

Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases

M Låg, J Øvrevik, M Refsnes, JA Holme - Respiratory research, 2020 - Springer
Epidemiological studies have found strong associations between air pollution and
respiratory effects including development and/or exacerbation of asthma and chronic …

Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant-and non-oxidant-mediated triggering mechanisms

J Øvrevik, M Refsnes, M Låg, JA Holme, PE Schwarze - Biomolecules, 2015 - mdpi.com
Inflammation is considered to play a central role in a diverse range of disease outcomes
associated with exposure to various types of inhalable particulates. The initial mechanisms …

Potential role of polycyclic aromatic hydrocarbons as mediators of cardiovascular effects from combustion particles

JA Holme, BC Brinchmann, M Refsnes, M Låg… - Environmental …, 2019 - Springer
Air pollution is the most important environmental risk factor for disease and premature death,
and exposure to combustion particles from vehicles is a major contributor. Human …

[HTML][HTML] Lung cancer associated with combustion particles and fine particulate matter (PM2. 5)-The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl …

JA Holme, J Vondráček, M Machala… - Biochemical …, 2023 - Elsevier
Air pollution is the leading cause of lung cancer after tobacco smoking, contributing to 20%
of all lung cancer deaths. Increased risk associated with living near trafficked roads …

Oxidative/nitrosative stress and immuno-inflammatory pathways in depression: treatment implications

G Anderson, M Maes - Current pharmaceutical design, 2014 - ingentaconnect.com
This paper reviews recent work on the biological underpinnings of clinical depression
emphasizing the crucial role of immunoinflammatory and oxidative and nitrosative stress …

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in …

I Moffat, NL Chepelev, S Labib… - Critical reviews in …, 2015 - Taylor & Francis
Toxicogenomics is proposed to be a useful tool in human health risk assessment. However,
a systematic comparison of traditional risk assessment approaches with those applying …

Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit/hyperactivity disorder (ADHD): Need for novel strategies for mechanisms and …

O Myhre, M Låg, GD Villanger, B Oftedal… - Toxicology and applied …, 2018 - Elsevier
Epidemiological studies have demonstrated that air pollution particulate matter (PM) and
adsorbed toxicants (organic compounds and trace metals) may affect child development …

[HTML][HTML] Update on vascular endothelial Ca2+ signalling: A tale of ion channels, pumps and transporters

F Moccia, R Berra-Romani, F Tanzi - World journal of biological …, 2012 - ncbi.nlm.nih.gov
A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …

Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in develo** zebrafish

BC Goodale, SC Tilton, MM Corvi, GR Wilson… - Toxicology and applied …, 2013 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components
of fossil fuels and by-products of combustion. These multi-ring chemicals differentially …