Innovative Cyanine-Based Fluorescent Dye for Targeted Mitochondrial Imaging and Its Utility in Whole-Brain Visualization

X Yan, X Chen, Z Shan, L Bi - ACS omega, 2024 - ACS Publications
Conducting in vivo brain imaging can be a challenging task due to the complexity of brain
tissue and the strict requirements for safe and effective imaging agents. However, a new …

Structural Reorganization Mechanism of the Aβ42 Fibril Mediated by N-Substituted Oligopyrrolamide ADH-353

A Dabas, B Goyal - ACS Chemical Neuroscience, 2024 - ACS Publications
The inhibition of amyloid-β (Aβ) fibrillation and clearance of Aβ aggregates have emerged
as a potential pharmacological strategy to alleviate Aβ aggregate-induced neurotoxicity in …

Advances in Synthesis and anti-Alzheimer's Potential of Functionalized Benzofurans: A Recent Overview

P Kushwaha, R Yadav, A Bhardwaj, D Khan - Synlett, 2025 - thieme-connect.com
Alzheimer's disease (AD) comes under progressive neurodegenerative disorders which is
the leading cause of dementia affecting the aged population. The available drugs for AD …

Exploring multitarget strategies for membrane protection in Alzheimer's disease

P Zambrano - ACS Chemical Neuroscience, 2023 - ACS Publications
The exploration of multitarget molecules presents a promising avenue in the quest for
effective therapeutic strategies against Alzheimer's disease (AD), a multifactorial …

Targeting and Imaging Mitochondria with a Novel Cyanine-based Fluorescent Dye and Its Application to Whole Brain Imaging

X Yan, X Chen, Z Shan, L Bi - bioRxiv, 2023 - biorxiv.org
In vivo, brain imaging poses several challenges due to the complexity of brain tissue and the
requirements for effective and safe imaging. In this manuscript, we reported on develo** a …