For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Microglia are the brain's resident macrophages, which guide various developmental
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …

Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the
develo** human cortex that contribute to its cellular diversity and evolutionary expansion …

Apical–basal progenitor cell polarity establishes key features of the radial and laminar
architecture of the develo** human cortex. The unique diversity of cortical stem cell …

Human dental pulp stem cells (hDPSCs) are some of the most promising stem cell types for
regenerative therapies given their ability to grow in the absence of serum and their realistic …

Microcephaly or reduced head circumference results from a multitude of abnormal
developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal …

This paper describes the contemporary state of knowledge regarding processes that
regulate normal development of the embryonic–fetal central nervous system (CNS). The …

Corticogenesis is one of the most critical and complicated processes during embryonic brain
development. Any slight impairment in corticogenesis could cause neurodevelopmental …