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Emerging diagnostics and therapeutics for Alzheimer disease
Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …
strategies that slow or prevent its clinical progression have largely remained elusive, until …
The amyloid cascade hypothesis: an updated critical review
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …
disease have created excitement and have been heralded as corroboration of the amyloid …
The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis
To promote new thinking of the pathogenesis of Alzheimer's disease (AD), we examine the
central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by …
central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by …
Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …
Microglia in Alzheimer's disease: Pathogenesis, mechanisms, and therapeutic potentials
J Miao, H Ma, Y Yang, Y Liao, C Lin, J Zheng… - Frontiers in aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …
If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
Strong genetic evidence supports an imbalance between production and clearance of
amyloid β-protein (Aβ) in people with Alzheimer disease (AD). Microglia that are potentially …
amyloid β-protein (Aβ) in people with Alzheimer disease (AD). Microglia that are potentially …
Blood-brain barrier: from physiology to disease and back
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
[HTML][HTML] Adult hippocampal neurogenesis in aging and Alzheimer's disease
Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the
millions of affected individuals. Progressive memory impairment in AD patients is associated …
millions of affected individuals. Progressive memory impairment in AD patients is associated …
Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases
Two phase-III clinical trials with anti-amyloid peptide antibodies have met their primary goal,
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …