Targeting galectin-driven regulatory circuits in cancer and fibrosis

KV Mariño, AJ Cagnoni, DO Croci… - Nature Reviews Drug …, 2023 - nature.com
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics

M Overchuk, G Zheng - Biomaterials, 2018 - Elsevier
Despite rapid advancements in the field of nanotechnology, there is mounting frustration in
the scientific community regarding the translational impact of nanomedicine. Modest …

[HTML][HTML] Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world

M Prasad, UP Lambe, B Brar, I Shah… - Biomedicine & …, 2018 - Elsevier
In recent years nanotechnology has revolutionized the healthcare strategies and envisioned
to have a tremendous impact to offer better health facilities. In this context, medical …

Biomimetic solid-state nanochannels for chemical and biological sensing applications

G Laucirica, YT Terrones, V Cayón, ML Cortez… - TrAC Trends in …, 2021 - Elsevier
Biomimetic solid-state nanochannels enable new modalities for biosensing. In the last
decade, these nanofluidic architectures have been widely studied due to their rapid and …

Particle targeting in complex biological media

Q Dai, N Bertleff‐Zieschang… - Advanced …, 2018 - Wiley Online Library
Over the past few decades, nanoengineered particles have gained increasing interest for
applications in the biomedical realm, including diagnosis, imaging, and therapy. When …

The role of galectin-1 in cancer progression, and synthetic multivalent systems for the study of galectin-1

JM Cousin, MJ Cloninger - International journal of molecular sciences, 2016 - mdpi.com
This review discusses the role of galectin-1 in the tumor microenvironment. First, the
structure and function of galectin-1 are discussed. Galectin-1, a member of the galectin …

Chagas disease diagnostic applications: present knowledge and future steps

V Balouz, F Agüero, CA Buscaglia - Advances in parasitology, 2017 - Elsevier
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

Recent advances on smart glycoconjugate vaccines in infections and cancer

M Anderluh, F Berti, A Bzducha‐Wróbel… - The FEBS …, 2022 - Wiley Online Library
Vaccination is one of the greatest achievements in biomedical research preventing death
and morbidity in many infectious diseases through the induction of pathogen‐specific …

Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Prognosis and Therapy

G Poiroux, A Barre, EJM Van Damme… - International journal of …, 2017 - mdpi.com
Aberrant O-glycans expressed at the surface of cancer cells consist of membrane-tethered
glycoproteins (T and Tn antigens) and glycolipids (Lewis a, Lewis x and Forssman …

Carrier diversity and chemical ligations in the toolbox for designing tumor-associated carbohydrate antigens (TACAs) as synthetic vaccine candidates

R Roy, L Mousavifar - Chemical Society Reviews, 2023 - pubs.rsc.org
This review highlights the recent development in the use of carriers of increasing simplicities
and versatile chemical ligation processes leading to synthetic vaccine candidates against …