Cholesterol is an essential structural component of membranes that contributes to
membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the …

Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

The I148M variant of PNPLA3 is closely associated with hepatic steatosis. Recent evidence
indicates that the I148M mutant functions as an inhibitor of PNPLA2/ATGL-mediated …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Cancer is one of the primary causes of death worldwide, and its incidence continues to
increase yearly. Despite significant advances in research, the search for effective and …

High cholesterol is a major risk factor for cardiovascular disease. Currently, no drug lowers
cholesterol through directly promoting cholesterol excretion. Human genetic studies have …

The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …

Lipid metabolism has been associated with the cyclic guanosine monophosphate (GMP)-
AMP synthase (cGAS) stimulator of interferon genes (STING) DNA-sensing pathway, but our …

INTRODUCTION High-density lipoprotein (HDL) participates in cholesterol homeostasis and
may also have anti-inflammatory or anti-microbial roles through its interaction with numerous …

Non-alcoholic fatty liver disease (NAFLD) is an 'umbrella'term, comprising a spectrum
ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and …