Neurological conditions associated with HIV remain major contributors to morbidity and
mortality and are increasingly recognized in the aging population on long-standing …

HIV persistence in the CNS despite antiretroviral therapy may cause neurological disorders
and poses a critical challenge for HIV cure. Understanding the pathobiology of HIV-infected …

A growing literature suggests a relationship between HIV-infection and a molecular profile of
age acceleration. However, despite the widely known high prevalence of HIV-related brain …

Premature end-organ disease among PLWH has been repeatedly associated with higher
levels of blood biomarkers reflecting inflammation and immune activation, which, despite …

Objective: Methamphetamine and cannabis are two widely used substances among people
living with HIV (PLWH). Whereas methamphetamine use has been found to worsen HIV …

Highly active anti-retroviral therapy (HAART) is very effective in suppressing HIV-1
replication in patients. However, continuous HAART is required to prevent viral rebound …

Biological evolution of the microbiome continually drives the emergence of human viral
pathogens, a subset of which attack the nervous system. The sheer number of pathogens …

Evidence from epidemiological studies on the general population suggests that midlife
cardiovascular disease (CVD) and/or metabolic syndrome (MetS) are associated with an …

There is currently no cure for HIV infection although adherence to effective antiretroviral
therapy (ART) suppresses replication of the virus in blood, increases CD4+ T-cell counts …

HIV-associated neurocognitive disorders (HAND) is a term used to describe a variety of
neurological impairments observed in HIV-infected individuals. The pathogenic mechanisms …