Highlights•Advances in ALR mediated inflammasome activation in response to viral
DNA.•Viral virulence factors that impair inflammasome activation.•Host regulation of …

Autophagy, a catabolic process by which a cell “eats” itself, turning over its own cellular
constituents, plays a key role in cellular homeostasis. In an effort to maintain normal cellular …

Autophagy is an essential component of host innate and adaptive immunity. Viruses have
developed diverse strategies for evading or utilizing autophagy for survival. The response of …

A majority of the world population is infected with herpes simplex viruses (HSV; human
herpesvirus types 1 and 2). These viruses, perhaps best known for their manifestation in the …

Autophagy refers to the conserved, multi-step mechanism that delivers cytosolic cargoes to
vesicles of the endo-lysosomal system for degradation. It maintains cellular homeostasis by …

Abstract Herpes simplex virus-1 (HSV-1) is a human pathogen that utilizes several strategies
to circumvent the host immune response. An immune evasion mechanism employed by HSV …

Inflammasomes play important roles in resisting infections caused by various pathogens.
HSV-1 is a highly contagious virus among humans. The process by which HSV-1 particles …

Background Rabies virus (RABV) is reported to encode five phosphoproteins (P), which are
involved in viral genomic replication, axonal transport, oxidative stress, interferon …

Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death, which
is an important natural immune response. Pyroptosis plays a major role in combating …

Inflammasomes are cytosolic multiprotein platforms with pivotal roles in infectious diseases.
Activation of inflammasomes results in proinflammatory cytokine signaling and pyroptosis …