MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration

HH Genedy, P Humbert, B Laoulaou, B Le Moal… - Advanced Drug Delivery …, 2024 - Elsevier
Low back pain stands as a pervasive global health concern, afflicting almost 80% of adults
at some point in their lives with nearly 40% attributable to intervertebral disc degeneration …

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and …

AJ Ferrari, DF Santomauro, A Aali, YH Abate… - The Lancet, 2024 - thelancet.com
Background Detailed, comprehensive, and timely reporting on population health by
underlying causes of disability and premature death is crucial to understanding and …

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of …

M Brauer, GA Roth, AY Aravkin, P Zheng, KH Abate… - The Lancet, 2024 - thelancet.com
Background Understanding the health consequences associated with exposure to risk
factors is necessary to inform public health policy and practice. To systematically quantify the …

[КНИГА][B] WHO guideline for non-surgical management of chronic primary low back pain in adults in primary and community care settings

World Health Organization - 2023 - books.google.com
The purpose of the guideline is to provide evidence-based recommendations on
nonsurgical interventions for chronic primary LBP (CPLBP) in adults, including older people …

The role of the brain-derived neurotrophic factor in chronic pain: links to central sensitization and neuroinflammation

HY **ong, J Hendrix, S Schabrun, A Wyns… - Biomolecules, 2024 - mdpi.com
Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …

Virtual reality in acute and chronic pain medicine: an updated review

S Moreau, A Thérond, IH Cerda, K Studer… - Current Pain and …, 2024 - Springer
Abstract Purpose of Review This review critically analyzes the recent literature on virtual
reality's (VR) use in acute and chronic pain management, offering insights into its efficacy …

Musculoskeletal health: an ecological study assessing disease burden and research funding

AT Nguyen, IM Aris, BD Snyder, MB Harris… - The Lancet Regional …, 2024 - thelancet.com
Background Exacerbated by an aging population, musculoskeletal diseases are a chronic
and growing problem in the United States that impose significant health and economic …

[HTML][HTML] Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

M Izquierdo, P de Souto Barreto, H Arai… - The Journal of nutrition …, 2025 - Elsevier
Aging, a universal and inevitable process, is characterized by a progressive accumulation of
physiological alterations and functional decline over time, leading to increased vulnerability …