The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

BACKGROUND Chromatin is the essential medium through which transcription factors,
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy.
Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) …

Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Abstract DNA methyltransferases DNMT3A-and DNMT3B-mediated DNA methylation
critically regulate epigenomic and transcriptomic patterning during development. The …