The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell
death that occurs during mitosis. Here, we propose that mitotic catastrophe results from a …

Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of
mutations conferring aggressive or drug-resistant phenotypes during cancer evolution …

Results To follow the fate of live cells that missegregate chromosomes, we generated
HCT116 cells that expressed LacIGFP and had multiple copies of lacO integrated into a …

Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to
breast cancers. The most frequent aberration was at chromosome 3p22-25; of ten cases with …

Increased 4N (G2/tetraploid) cell populations have been postulated to be genetically
unstable intermediates in the progression to many cancers, but the mechanism by which …

It has been hypothesized that neoplastic progression develops as a consequence of an
acquired genetic instability and the subsequent evolution of clonal populations with …

Cell cycle checkpoints enhance genetic fidelity by causing arrest at specific stages of the cell
cycle when previous events have not been completed. The tumor suppressor p53 has been …

Genomic instability is intrinsically linked to significant alterations in apoptosis control.
Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic …

The incidence of adenocarcinoma of the esophagus has been increasing in develo**
countries over the last three decades and probably reflects a genuine increase in the …

OBJECTIVES: Most patients with Barrett's esophagus do not progress to cancer, but those
who do seem to have markedly increased survival when cancers are detected at an early …