Genetics of rheumatoid arthritis
L Padyukov - Seminars in immunopathology, 2022 - Springer
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …
A summary on the genetics of systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and Sjögren's syndrome
Systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and Sjögren's
syndrome are four major autoimmune rheumatic diseases characterized by the presence of …
syndrome are four major autoimmune rheumatic diseases characterized by the presence of …
Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning
Methods of estimating polygenic scores (PGSs) from genome-wide association studies are
increasingly utilized. However, independent method evaluation is lacking, and method …
increasingly utilized. However, independent method evaluation is lacking, and method …
Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
W ** a precise understanding of the cell states where noncoding …
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or
ACPA positive) and seronegative subsets. Methods We performed a genome-wide …
ACPA positive) and seronegative subsets. Methods We performed a genome-wide …
Loss of gut barrier integrity in lupus
Systemic Lupus Erythematosus is a complex autoimmune disease and its etiology remains
unknown. Increased gut permeability has been reported in lupus patients, yet whether it …
unknown. Increased gut permeability has been reported in lupus patients, yet whether it …
Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly
associated with immune-mediated disorders. In this study, we implemented multitrait joint …
associated with immune-mediated disorders. In this study, we implemented multitrait joint …