Mechanisms and regulation of RNA condensation in RNP granule formation
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
multiple aspects of RNA metabolism and are linked to memory, development, and disease …
[HTML][HTML] Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome
Survival of the African trypanosome within its mammalian hosts, and hence transmission
between hosts, relies upon antigenic variation, where stochastic changes in the composition …
between hosts, relies upon antigenic variation, where stochastic changes in the composition …
[HTML][HTML] Modulation of RNA condensation by the DEAD-box protein eIF4A
Stress granules are condensates of non-translating mRNAs and proteins involved in the
stress response and neurodegenerative diseases. Stress granules form in part through …
stress response and neurodegenerative diseases. Stress granules form in part through …
UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks
(DSBs) occurring within transcriptional active regions of the genome. The induction of DNA …
(DSBs) occurring within transcriptional active regions of the genome. The induction of DNA …
N6-Methyladenosine-modified lncRNA LINREP promotes Glioblastoma progression by recruiting the PTBP1/HuR complex
X Ji, Z Liu, J Gao, X Bing, D He, W Liu… - Cell Death & …, 2023 - nature.com
Glioblastoma multiforme (GBM) is acknowledged as the most aggressive primary brain
tumor in adults. It is typically characterized by the high heterogeneity which corresponds to …
tumor in adults. It is typically characterized by the high heterogeneity which corresponds to …
Nonsense-mediated RNA decay factor UPF1 is critical for posttranscriptional and translational gene regulation in Arabidopsis
Nonsense-mediated RNA decay (NMD) is an RNA control mechanism that has also been
implicated in the broader regulation of gene expression. Nevertheless, a role for NMD in …
implicated in the broader regulation of gene expression. Nevertheless, a role for NMD in …
Survey of the binding preferences of RNA-binding proteins to RNA editing events
X Hu, Q Zou, L Yao, X Yang - Genome biology, 2022 - Springer
Background Adenosine-to-inosine (A-to-I) editing is an important RNA posttranscriptional
process related to a multitude of cellular and molecular activities. However, systematic …
process related to a multitude of cellular and molecular activities. However, systematic …
Tau‐induced deficits in nonsense‐mediated mRNA decay contribute to neurodegeneration
Introduction While brains of patients with Alzheimer's disease and related tauopathies have
evidence of altered RNA processing, we lack a mechanistic understanding of how altered …
evidence of altered RNA processing, we lack a mechanistic understanding of how altered …
UPF1-mediated RNA decay—Danse Macabre in a cloud
D Lavysh, G Neu-Yilik - Biomolecules, 2020 - mdpi.com
Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA
decay pathways that unfold around a common central effector protein called UPF1. While …
decay pathways that unfold around a common central effector protein called UPF1. While …
The biological functions of nonsense-mediated mRNA decay in plants: RNA quality control and beyond
Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved quality control
pathway that inhibits the expression of transcripts containing premature termination codon …
pathway that inhibits the expression of transcripts containing premature termination codon …