ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and
leukemia. RUNX1 mutations can be early events, creating preleukemic stem cells that …

Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and
tumor relapse. It has been suggested that gliomas are driven by a rare subset of tumor cells …

RUNX1 is generally considered a tumor suppressor in myeloid neoplasms. Inactivating
RUNX1 mutations have frequently been found in patients with myelodysplastic syndrome …

The Runt‐related transcription factors (RUNX) belong to an ancient family of metazoan
genes involved in developmental processes. Through multiple protein‐interacting partners …

Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic
regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain …

The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key
regulators of development and can function as either tumor suppressors or oncogenes in …

Since its discovery from a translocation in leukemias, the runt-related transcription factor
1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in …

The study of RUNX3 in tumor pathogenesis is a rapidly expanding area of cancer research.
Functional inactivation of RUNX3—through mutation, epigenetic silencing, or cytoplasmic …