Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion

P Makvandi, M Kirkby, ARJ Hutton, M Shabani… - Nano-Micro Letters, 2021 - Springer
Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety
of active compounds into the skin. To serve as a substitute for common hypodermic needles …

[HTML][HTML] Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development

E Larrañeta, REM Lutton, AD Woolfson… - Materials Science and …, 2016 - Elsevier
Transdermal drug delivery offers a number of advantages for the patient, due not only its non-
invasive and convenient nature, but also factors such as avoidance of first pass metabolism …

An overview of microneedle applications, materials, and fabrication methods

ZF Rad, PD Prewett, GJ Davies - Beilstein journal of …, 2021 - beilstein-journals.org
Microneedle-based microdevices promise to expand the scope for delivery of vaccines and
therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics …

Microneedles for painless transdermal immunotherapeutic applications

H Amani, MA Shahbazi, C D'Amico, F Fontana… - Journal of Controlled …, 2021 - Elsevier
Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

Biodegradable 3D printed polymer microneedles for transdermal drug delivery

MA Luzuriaga, DR Berry, JC Reagan, RA Smaldone… - Lab on a Chip, 2018 - pubs.rsc.org
Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug
delivery devices that promise a painless and sanitary alternative to syringes; however …

[HTML][HTML] Microneedle-based delivery: An overview of current applications and trends

AJ Guillot, AS Cordeiro, RF Donnelly, MC Montesinos… - Pharmaceutics, 2020 - mdpi.com
Microneedle arrays (MNA) are considered as one of the most promising resources to
achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally …

Poloxamer hydrogels for biomedical applications

E Russo, C Villa - Pharmaceutics, 2019 - mdpi.com
This review article focuses on thermoresponsive hydrogels consisting of poloxamers which
are of high interest for biomedical application especially in drug delivery for ophthalmic …

Microneedles for intradermal and transdermal drug delivery

TM Tuan-Mahmood, MTC McCrudden… - European Journal of …, 2013 - Elsevier
The formidable barrier properties of the uppermost layer of the skin, the stratum corneum,
impose significant limitations for successful systemic delivery of broad range of therapeutic …

Insulin delivery systems combined with microneedle technology

X **, DD Zhu, BZ Chen, M Ashfaq, XD Guo - Advanced drug delivery …, 2018 - Elsevier
Diabetes, a metabolic disorder of glucose, is a serious chronic disease and an important
public health problem. Insulin is one of the hormones for modulating blood glucose level …

Microneedles: Characteristics, materials, production methods and commercial development

A Tucak, M Sirbubalo, L Hindija, O Rahić, J Hadžiabdić… - Micromachines, 2020 - mdpi.com
Although transdermal drug delivery systems (DDS) offer numerous benefits for patients,
including the avoidance of both gastric irritation and first-pass metabolism effect, as well as …