Infantile spasms (IS or epileptic spasms during infancy) were first described by Dr. William
James West (aka West syndrome) in his own son in 1841. While rare by definition (occurring …

Introduction Infantile spasm (IS) is an epileptic syndrome with typical onset within the first 2
years of life. This condition might be caused by several etiologies. IS is associated with …

The enantioselective synthesis of chiral 4-substituted 4, 5-dihydro-1 H-[1, 5] benzodiazepin-
2 (3 H)-ones via asymmetric hydrogenation catalyzed by the Pd/f-spiroPhos complex in the …

Hormone therapies and vigabatrin are first-line agents in infantile spasms, but more than
one-third of patients fail to respond to these treatments. This was a retrospective study of …

(1) Background: West syndrome is a severe, refractory, epileptic syndrome that usually
appears in infancy or early childhood. ACTH is one of the more effective drugs for treating …

Objective To evaluate the effectiveness and tolerability of clobazam therapy in the pediatric
population in terms of seizure semiology, epileptic syndromes, and etiological subgroups …

Clobazam (CLB) is an effective anticonvulsant used as an adjunctive treatment for several
seizures and epilepsy syndromes. Data are limited on efficacy and safety of CLB as add-on …

目的探讨氯巴占附加治疗儿童难治性癫痫的有效性和安全性, 为临床安全, 合理用药提供参考.
方法计算机检索PubMed, The Cochrane Library, Embase, **知网, 维普网 …

婴儿癫痫性痉挛综合征(IESS) 是最**几年提出的一个新概念, 是一种独特的,
具有年龄特异性的难治性癫痫综合征. **年来, 随着分子生物学, 神经免疫学的发展以及抗癫痫 …

OBJECTIVE: To investigate the factors in first-time adrenocorticotropic hormone (ACTH)
therapy and their influence on spasm control time in infants with infantile spasms …